TIL In the song "Misunderstood", John Petrucci wrote the guitar solo, reversed it, learned and recorded the reversed version, then reversed the recording. The result is a solo that sounds like the original but with a unique sound.

https://en.wikipedia.org/wiki/Six_Degrees_of_Inner_Turbulence#Track_listing
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https://www.reddit.com/r/todayilearned/comments/1gfw37r/til_in_the_song_misunderstood_john_petrucci_wrote/