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Relationship between major depressive disorder & myalgic encephalomyelitis/chronic fatigue syndrome: a two-sample mendelian randomization study analysis

https://www.nature.com/articles/s41598-025-85217-6

"The results of the MR analysis revealed no causal relationship between MDD & ME/CFS"

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME
Abstract Major depressive disorder (MDD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently occur together; yet their causal relationship remains unclear. To investigate the potential genetic causal link between these conditions, we conducted a two-sample Mendelian randomization (MR) analysis. Summary data from Genome-Wide Association Studies (GWAS) for MDD were sourced from the UK Biobank and the Psychiatric Genomics Consortium, while GWAS data for ME/CFS were retrieved from the UK Biobank. Inverse-variance weighting (IVW), the MR-Egger method, and weighted median, simple and weighted modes were used to perform the MR analysis. In addition, Cochrane’s Q-test was used to detect heterogeneity among the MR results. Horizontal pleiotropy was detected using the MR-Egger intercept and the MR pleiotropy residual sum and outlier (MR-PRESSO) tests. Leave-one-out analysis was performed to investigate the sensitivity of the association between MDD and ME/CFS. The results of the MR analysis revealed no causal relationship between MDD and ME/CFS. The pleiotropy test revealed that causality bias was improbable, and no evidence of heterogeneity was found among the genetic variants. Finally, the leave-one-out test confirmed the stability and robustness of our findings.

Relationship between major depressive disorder and myalgic encephalomyelitis/chronic fatigue syndrome: a two-sample mendelian randomization study analysis - Scientific Reports

Scientific Reports - Relationship between major depressive disorder and myalgic encephalomyelitis/chronic fatigue syndrome: a two-sample mendelian randomization study analysis
Nature
#cfs #mecfs #pwme #MyalgicEncephalomyelitis #chronicfatiguesyndrome @MECFS group
Tom Kindlon
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“Study Finds No Causal Link Between Depression And Chronic Fatigue Syndrome: Recent genetic analysis reveals major depressive disorder does not cause myalgic encephalomyelitis/chronic fatigue syndrome”

https://evrimagaci.org/tpg/study-finds-no-causal-link-between-depression-and-chronic-fatigue-syndrome-149447

#MEcfs #CFS
@mecfs

Study Finds No Causal Link Between Depression And Chronic Fatigue Syndrome

Major depressive disorder (MDD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are two debilitating conditions often found overlapping, yet whether…
The Pinnacle Gazette
#cfs #mecfs @MECFS group
Hugs4friends ♾🇺🇦 🇵🇸😷
...however, I'd be willing to bet that mecfs would lead to mdd. @mecfs
@MECFS group
Firehorseart lives!
Yes, it's possible if patients are constantly met with a lack of support for their condition.

The 2021 NICE guidelines should have helped change that but that also depends on doctors being up to date with the information.

@tomkindlon @mecfs
@Tom Kindlon @MECFS group
Hugs4friends ♾🇺🇦 🇵🇸😷
Going by what I've read, indifference is standard from GPs/Clinicians/Primary Physicians...if they don't actively misdiagnose. @tomkindlon @mecfs
@Tom Kindlon @MECFS group
Firehorseart lives!
Given that GPs typically have 10 mins to diagnose and prescribe on a condition that's been ridiculed for many years, that makes sense.

@tomkindlon @mecfs
@Tom Kindlon @MECFS group
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